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The phenolics-rich fraction of Khaya senegalensis A. Juss (Meliaceae) stem bark extract (pfks) has been previously reported to possess potent antitrypanosomal activity at 300mg/kg body weight (bw) but could not completely prevent disease-induced anemia and organ damage in addition to being slightly hepatotoxic at the same dose. Therefore, the effects of a combined administration of low dose pfks and...
The herbal medicinal product Myrrhinil-Intest®, a combination of myrrh, chamomile flower extract and coffee charcoal is used for the maintenance therapy of inflammatory bowel disease. In vitro studies revealed that the herbal components influence chemokine signaling of human macrophages as part of an anti-inflammatory mechanism. However, the occurrence of synergistic effects remains unexplored.The...
At the conclusion of all drug research is the ‘approval of the (new) drug’. Therefore, for scientists, it’s unavoidable to think about the process of regulation. First, keep in mind that all regulators are (very) conservative. All regulators have learned the lesson: avoid pharmacovigilance cases. Don’t take risks; it will infringe on your career. Non-approval is the best way to avoid failures. To...
Herbal medicines have been used from ancient times for the management of several disease and ailments along with prescribed medicine without consulting the physicians. Berberis aristata DC. has been widely used in management of diabetes as alternative therapy in India and other Asian countries. An approach has been made to evaluate the possible cytochrome P450 (CYP450) enzyme inhibition potential...
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